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Neutrophils

  • Half life in circulation 6-12 hours

Functions

  • 1st Wave of host defence
  • Chemotaxis
    • contraction of cytoplasmic microtubules
    • gel/sol changes
    • controlled by Ca++ and cyclic nucleotides
  • Adhesion to micro-organisms
    • opsonised by C3b and Fc of antibodies
  • Phagocytosis
    • sends out pseudopodia
    • phagosome fuses with lyososome
  • Intracellular killing
    • oxidative burst
    • lysozyme
    • lactoferrin
    • cationic proteins
    • low pH
  • Release Products
    • elastase
    • collagenase
    • activate factor XII

Disorders

 

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