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Amoxicillin

• broad-spectrum penicillin

Route

• PO

Spectrum

• some Gram negative
• some Gram positive

Resistance

• Staphylococcus
• Escherichia coli (50%)
• H. influenzae (15%)

Use

• Streptococcus pneumoniae
  • exacerbation of chronic bronchitis
  • middle ear infections
• endocarditis prophylaxis

Side Effects

• nausea
• vomiting
• diarrhoea
• rashes
  • esp. with infectious mononucleosis
• antibiotic-associated colitis
• hypersensitivity
  • urticaria
  • fever
  • joints pains
  • angioedema
  • Anaphylaxis
  • haemolytic anaemia
  • interstitial Nephritis
• blood dyscrasias
  • neutropenia
  • thrombocytopenia
  • coagulation disturbance
• CNS toxicity