Infectious Mononucleosis

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(Glandular fever)

• caused by Epstein-Barr Virus

Clinical Features

History

• fever
• headache
• malaise
• sore throat

Examination

• palatal petechiae
• transient macular rash
  • esp after Ampicillin (90%)
• Cervical Lymphadenopathy
• Splenomegaly

Complications

• mild hepatitis
• meningitis
• encephalitis
• mesenteric adenitis
• splenic rupture

Investigations

• Paul-Bunnell reaction / Monospot test
• Epstein-Barr Virus serology

Treatment

• corticosteroids
  • if neurological involvement
    • Encephalitis
    • Meningitis
    • Guillain-Barre Syndrome
  • marked Thrombocytopenia
  • Haemolysis

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