Drugs Acting On Urogenital System

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Drugs Acting on Urogenital System

Urological Pain

• opiates
  • morphine
  • pethidine (relaxes smooth muscle)
• Diclofenac parenterally
• Lignocaine topically during catheterisation

Alkalinisation of Urine

• potassium citrate for relieve of discomfort of dysuria / UTI

Acidification of Urine

• vitamin C (>2g)
  • causes GI disturbance (diarrhoea)

Urinary Retention

• acute retention painful and treated by catheterisation
• chronic retention usually painless - treated with drugs that increase detrusor tone
• Benign Prostatic Hyperplasia -  Alpha Blockers, androgen antagonists (Finasteride) or surgery

Chronic Retention

• Muscarinic agonists
• Anticholinesterases

Benign Prostatic Hyperplasia

• Alpha Blockers
• Finasteride

Incontinence

• Muscarinic Antagonists
• Tricyclic Antidepressants

Vaginal Atrophy

• topical oestrogens
• oral progestogens

Anti-Infective Drugs

Fungal infections

• Candida vulvitis
  • topical cream
• Vaginal candidiasis
  • anti-fungal pessaries
  • cream high in vagina
• Drugs
  • Imidazoles
  • Nystatin

Other infections

• Trichomonas
  • Metronidazole
• Bacterial
  • Metronidazole
• Viral
  • Acyclovir

Impotence

Contraception

• Oral Contraceptive Pill
• Post-Coital Contraception

Hormone Replacement Therapy

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