Drugs Causing Liver Damage

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Drugs Causing Liver Damage

• Zone 3 necrosis
  • carbon tetrachloride
  • Amanita mushrooms
  • paracetamol
  • Salicylates
  • Piroxicam
  • Cocaine
• Zone 1 necrosis
  • Ferrous sulphate
• Microvesicular fat
  • sodium valproate
  • tetracyclines
• 'alcoholic' hepatitis
  • perhexiline maleate
  • amiodarone
  • synthetic oestrogens
  • nifedipine
• Fibrosis
  • methotrexate
  • other cytotoxics
  • arsenic
  • vitamin A
  • retinoids
• Heparlobatum
  • combination chemotherapy
• Vascular sinusoidal dilatation
  • contraceptives
  • anabolic steroids
    • danazol
  • azathioprine
• Peliosis hepatis (dilatation of sinusoids to form blood-filled lakes)
  • oral contraceptives
  • anabolic steroids
    • danazol
  • azathioprine
• Veno-occlusive
  • 'bush tea'
  • cytotoxics
    • azathioprine
    • cyclophosphamide
• Acute Hepatitis
  • Isoniazid
  • Rifampicin
  • Methyldopa
  • Atenolol
  • Enalapril
  • Verapamil
  • Ketoconazole
  • Cytotoxics
  • Clonazepam
  • Disulfiram
  • Niacin
  • Halothane
• Chronic Hepatitis
  • methyldopa
  • nitrofurantoin
  • fenofibrate
  • isoniazid
• General Hypersensitivity
  • Sulphonamides
  • Penicillins
  • NSAIDs
  • Allopurinol
  • Anti-thyroid
    • propylthiouracil
    • carbimazole
  • Quinine
  • Diltiazem
  • Anticonvulsants
    • phenytoin
• Canalicular cholestasis
  • sex hormones
  • Cyclosporin A
• Hepato-canalicular cholestasis
  • chlorpromazine
  • haloperidol
  • erythromycin
  • cimetidine / ranitidine
  • nitrofurantoin
  • imipramine
  • azathioprine
  • oral hypoglycaemics
  • dextropropoxyphene
• Ductular cholestasis
  • benoxyprofen
• Biliary sludge
  • ceftriaxone
• Sclerosing cholangitis
  • 5-FU into hepatic artery
  • Thiabendazole into hydatid cysts
• Hepatic tumours
  • OCP with high hormone content
• HCC
  • contraceptive pill
  • Danazol

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